{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318434/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318434"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Endothelial TGFβ signaling regulates choroidal neovascularization severity via myeloid–endothelial interaction","description":"The blood-retinal barrier (BRB) is essential for maintaining retinal homeostasis, yet its disruption contributes to pathological angiogenesis in diseases such as neovascular age-related macular degeneration (nAMD). Here, we investigated how endothelial TGF-β signaling interacts with microglia to regulate choroidal neovascularization (CNV). Using a laser-induced CNV model in mice with endothelial-specific Tgfbr2 deletion (Tgfbr2∆EC) and concomitant microglia depletion via PLX5622, we demonstrate that loss of endothelial TGF-β signaling significantly exacerbates CNV, an effect fully rescued by microglia depletion. Bulk RNA sequencing and RNAscope analyses of CNV lesions identified fibrinogen alpha chain (Fga) as a microglia-derived factor upregulated exclusively in Tgfbr2∆EC mice. These findings suggest a TGF-β-dependent interaction between endothelial cells and microglia that promotes angiogenesis through microglia derived Fga expression.","dates":{"publication":"2026/07/15"},"accession":"GSE318434","cross_references":{"GSM":["GSM9494505","GSM9494527","GSM9494504","GSM9494526","GSM9494525","GSM9494503","GSM9494502","GSM9494524","GSM9494509","GSM9494508","GSM9494507","GSM9494529","GSM9494528","GSM9494506","GSM9494530","GSM9494534","GSM9494512","GSM9494511","GSM9494533","GSM9494510","GSM9494532","GSM9494531","GSM9494516","GSM9494538","GSM9494537","GSM9494515","GSM9494514","GSM9494536","GSM9494513","GSM9494535","GSM9494519","GSM9494518","GSM9494517","GSM9494539","GSM9494540","GSM9494501","GSM9494523","GSM9494522","GSM9494521","GSM9494520"],"GPL":["30172"],"GSE":["318434"],"taxon":["Mus musculus"],"PMID":["[42433372]"]}}