{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318514/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"," Expression profiling by high throughput sequencing"," Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318514"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Organ injury in systemic autoimmunity is mediated by stem-like CD8 T cells arising from tissue-draining lymph nodes","description":"Chronic antigen exposure in cancer and infection generates hypofunctional, stem-like CD8 T cells that replenish tissue effector cells for tumor or pathogen control. CD8 T cells infiltrate kidneys in systemic lupus erythematosus, but their origin, differentiation, and function remain incompletely understood. We identified in lupus-prone mice TCF1⁺ stem-like CD8 T cells in renal-draining lymph nodes that underwent TCR-dependent, antigen-driven expansion with differentiation into cytotoxic kidney-infiltrating cells that promoted tissue injury contingent on CD4 T cell help and IL-21/IL-15 signaling. CD8 T cell differentiation was marked by persistent AP-1 activity and cytotoxic function despite immune checkpoint upregulation. We found a parallel program of CD8 T cell differentiation in kidneys of patients with lupus nephritis, reflecting shared pathogenesis. This T cell differentiation program is analogous to that in chronic infections and cancer, indicating conservation across states of chronic antigen stimulation; however, CD8 T cells in systemic autoimmunity retain effector function despite terminal differentiation.","dates":{"publication":"2026/04/20"},"accession":"GSE318514","cross_references":{"GSM":["GSM9496926","GSM9496948","GSM9496949","GSM9496905","GSM9496927","GSM9496906","GSM9496928","GSM9496929","GSM9496907","GSM9496922","GSM9496944","GSM9496923","GSM9496945","GSM9496946","GSM9496924","GSM9496925","GSM9496947","GSM9496908","GSM9496909","GSM9496930","GSM9496931","GSM9496932","GSM9496910","GSM9496915","GSM9496937","GSM9496916","GSM9496938","GSM9496917","GSM9496939","GSM9496918","GSM9496911","GSM9496933","GSM9496912","GSM9496934","GSM9496935","GSM9496913","GSM9496914","GSM9496936","GSM9496919","GSM9496940","GSM9496941","GSM9496920","GSM9496942","GSM9496943","GSM9496921"],"GPL":["24247"],"GSE":["318514"],"taxon":["Mus musculus"],"PMID":["[42013863]"]}}