{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318515/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318515"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"TDP-43 regulates ferroptosis to modulate the malignant progression of lung adenocarcinoma","description":"Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality globally. TAR DNA-binding protein 43 (TDP-43) is involved in multiple tumor-associated biological processes, while its functional role and underlying mechanism in LUAD progression remain to be elucidated. Ferroptosis, a form of iron-dependent regulated cell death, plays a critical role in tumor development and progression. In this study, we investigated the regulatory effect of TDP-43 on ferroptosis and its subsequent impact on LUAD malignant progression. The expression pattern of TDP-43 in LUAD tissues and its correlation with clinical prognosis were analyzed. Functional experiments were performed to verify the effects of TDP-43 on LUAD cell proliferation, cell death and ferroptosis progression. Whole transcriptome sequencing combined with ferroptosis-related indicator detection was used to explore the regulatory mechanism of TDP-43 in LUAD ferroptosis. The results of this study reveal the regulatory role of TDP-43 in LUAD ferroptosis and malignant progression, providing experimental data and research basis for further exploration of LUAD pathogenesis and potential therapeutic targets.","dates":{"publication":"2026/08/26"},"accession":"GSE318515","cross_references":{"GSM":["GSM9496955","GSM9496951","GSM9496952","GSM9496953","GSM9496954","GSM9496950"],"GPL":["30209"],"GSE":["318515"],"taxon":["Homo sapiens"],"PMID":["[42585793]"]}}