{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318527/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318527"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Effect of CST3 knockout on gene expression in THP-1-derived macrophages","description":"To systematically investigate the biological role of CST3 in macrophages, we performed RNA-seq on THP-1-derived macrophages from wildtype (CST3+/+) and CST3 knockout (CST3-/-) backgrounds. Comparative transcriptomic analysis revealed differential expression of genes involved in inflammatory response upon CST3 loss. These findings provide a comprehensive resource for understanding the molecular mechanisms by which CST3 regulates macrophage phenotype and function, with potential implications for inflammatory diseases and immune modulation.","dates":{"publication":"2026/05/03"},"accession":"GSE318527","cross_references":{"GSM":["GSM9497144","GSM9497149","GSM9497146","GSM9497145","GSM9497148","GSM9497147"],"GPL":["28038"],"GSE":["318527"],"taxon":["Homo sapiens"]}}