GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318527/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318527GEOGSEfalseEffect of CST3 knockout on gene expression in THP-1-derived macrophagesTo systematically investigate the biological role of CST3 in macrophages, we performed RNA-seq on THP-1-derived macrophages from wildtype (CST3+/+) and CST3 knockout (CST3-/-) backgrounds. Comparative transcriptomic analysis revealed differential expression of genes involved in inflammatory response upon CST3 loss. These findings provide a comprehensive resource for understanding the molecular mechanisms by which CST3 regulates macrophage phenotype and function, with potential implications for inflammatory diseases and immune modulation.2026/05/03GSE318527GSM9497144GSM9497149GSM9497146GSM9497145GSM9497148GSM949714728038318527Homo sapiens