{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318618/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318618"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Multi-omic analysis reveals molecular subtypes with distinct immunological phenotypes in SLE","description":"Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by variability in clinical manifestations and underlying molecular mechanisms. To investigate this heterogeneity, we performed integrative multi-omic profiling—including epigenomic (EM-seq), transcriptomic (RNA-seq), and proteomic (Olink) analyses—on whole blood samples from over 700 SLE patients enrolled in two Phase III clinical trials. Using this approach, we identified three stable molecular endotypes of SLE, providing a framework for understanding disease subtypes and informing precision medicine strategies.","dates":{"publication":"2026/05/01"},"accession":"GSE318618","cross_references":{"GSM":["GSM9499221","GSM9499220","GSM9499223","GSM9499222","GSM9499229","GSM9499228","GSM9499225","GSM9499224","GSM9499227","GSM9499226","GSM9499232","GSM9499231","GSM9499234","GSM9499233","GSM9499230","GSM9499239","GSM9499236","GSM9499235","GSM9499238","GSM9499237","GSM9499001","GSM9499243","GSM9499000","GSM9499242","GSM9499003","GSM9499245","GSM9499244","GSM9499002","GSM9499241","GSM9499240","GSM9499009","GSM9499008","GSM9499247","GSM9499005","GSM9499004","GSM9499246","GSM9499249","GSM9499007","GSM9499006","GSM9499248","GSM9499012","GSM9499254","GSM9499253","GSM9499011","GSM9499014","GSM9499256","GSM9499255","GSM9499013","GSM9499250","GSM9499252","GSM9499010","GSM9499251","GSM9499019","GSM9499258","GSM9499016","GSM9499015","GSM9499257","GSM9499018","GSM9499017","GSM9499259","GSM9498572","GSM9498574","GSM9498573","GSM9498579","GSM9498576","GSM9498575","GSM9498578","GSM9498577","GSM9498583","GSM9498582","GSM9498585","GSM9498584","GSM9498581","GSM9498580","GSM9498587","GSM9498586","GSM9498589","GSM9498588","GSM9498594","GSM9498593","GSM9499201","GSM9498596","GSM9499200","GSM9498595","GSM9498590","GSM9498592","GSM9498591","GSM9499207","GSM9499206","GSM9499209","GSM9499208","GSM9499203","GSM9498598","GSM9498597","GSM9499202","GSM9499205","GSM9499204","GSM9498599","GSM9499210","GSM9499212","GSM9499211","GSM9499218","GSM9499217","GSM9499219","GSM9499214","GSM9499213","GSM9499216","GSM9499215","GSM9499061","GSM9499060","GSM9499067","GSM9499066","GSM9499069","GSM9499068","GSM9499063","GSM9499062","GSM9499065","GSM9499064","GSM9499070","GSM9499072","GSM9499071","GSM9499078","GSM9499077","GSM9499079","GSM9499074","GSM9499073","GSM9499076","GSM9499075","GSM9499081","GSM9499080","GSM9499083","GSM9499082","GSM9499089","GSM9499088","GSM9499085","GSM9499084","GSM9499087","GSM9499086","GSM9499092","GSM9499091","GSM9499094","GSM9499093","GSM9499090","GSM9499099","GSM9499096","GSM9499095","GSM9499098","GSM9499097","GSM9499023","GSM9499265","GSM9499264","GSM9499022","GSM9499267","GSM9499025","GSM9499024","GSM9499266","GSM9499261","GSM9499260","GSM9499021","GSM9499263","GSM9499020","GSM9499262","GSM9499269","GSM9499027","GSM9499026","GSM9499268","GSM9499029","GSM9499028","GSM9499270","GSM9499276","GSM9499034","GSM9499275","GSM9499033","GSM9499278","GSM9499036","GSM9499035","GSM9499277","GSM9499272","GSM9499030","GSM9499271","GSM9499032","GSM9499274","GSM9499273","GSM9499031","GSM9499038","GSM9499037","GSM9499279","GSM9499039","GSM9499281","GSM9499280","GSM9499287","GSM9499045","GSM9499044","GSM9499286","GSM9499047","GSM9499289","GSM9499046","GSM9499288","GSM9499041","GSM9499283","GSM9499040","GSM9499282","GSM9499043","GSM9499285","GSM9499284","GSM9499042","GSM9499049","GSM9499048","GSM9499290","GSM9499292","GSM9499050","GSM9499291","GSM9499298","GSM9499056","GSM9499055","GSM9499297","GSM9499058","GSM9499057","GSM9499299","GSM9499052","GSM9499294","GSM9499293","GSM9499051","GSM9499296","GSM9499054","GSM9499295","GSM9499053","GSM9499059","GSM9498808","GSM9498807","GSM9498809","GSM9498804","GSM9498803","GSM9498806","GSM9498805","GSM9498811","GSM9498810","GSM9498813","GSM9498812","GSM9498819","GSM9498818","GSM9498815","GSM9498814","GSM9498817","GSM9498816","GSM9498822","GSM9498821","GSM9498824","GSM9498823","GSM9498820","GSM9498829","GSM9498826","GSM9498825","GSM9498828","GSM9498827","GSM9498833","GSM9498832","GSM9498835","GSM9498834","GSM9498831","GSM9498830","GSM9498837","GSM9498836","GSM9498839","GSM9498838","GSM9498602","GSM9498844","GSM9498843","GSM9498601","GSM9498846","GSM9498604","GSM9498603","GSM9498845","GSM9498840","GSM9498600","GSM9498842","GSM9498841","GSM9498800","GSM9498802","GSM9498801","GSM9498649","GSM9498891","GSM9498890","GSM9498651","GSM9498893","GSM9498892","GSM9498650","GSM9498657","GSM9498899","GSM9498898","GSM9498656","GSM9498659","GSM9498658","GSM9498895","GSM9498653","GSM9498652","GSM9498894","GSM9498897","GSM9498655","GSM9498654","GSM9498896","GSM9498660","GSM9498662","GSM9498661","GSM9498668","GSM9498667","GSM9498669","GSM9498664","GSM9498663","GSM9498666","GSM9498665","GSM9498671","GSM9498670","GSM9498673","GSM9498672","GSM9498679","GSM9498678","GSM9498675","GSM9498674","GSM9498677","GSM9498676","GSM9498682","GSM9498681","GSM9498684","GSM9498683","GSM9498680","GSM9498689","GSM9498686","GSM9498685","GSM9498688","GSM9498687","GSM9498609","GSM9498606","GSM9498848","GSM9498605","GSM9498847","GSM9498608","GSM9498849","GSM9498607","GSM9498855","GSM9498613","GSM9498854","GSM9498612","GSM9498857","GSM9498615","GSM9498614","GSM9498856","GSM9498851","GSM9498850","GSM9498611","GSM9498853","GSM9498852","GSM9498610","GSM9498617","GSM9498859","GSM9498858","GSM9498616","GSM9498619","GSM9498618","GSM9498860","GSM9498866","GSM9498624","GSM9498623","GSM9498865","GSM9498626","GSM9498868","GSM9498625","GSM9498867","GSM9498620","GSM9498862","GSM9498861","GSM9498622","GSM9498864","GSM9498863","GSM9498621","GSM9498628","GSM9498869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