{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318678/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318678"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"mRNA 3ʹ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth dataset 6","description":"MicroRNAs direct downregulation of target mRNAs. Sometimes, however, this regulatory paradigm inverts, and a target RNA triggers degradation of a microRNA. This target-directed microRNA degradation (TDMD) requires ZSWIM8. Zswim8-/- mice exhibit reduced growth and perinatal lethality, accompanied by stabilization of >40 microRNAs. Nonetheless, studies of TDMD function in mammals have been limited because only two TDMD-triggering RNAs have been identified in mice. Here, we computationally identify and validate five new TDMD-triggering sites in mouse models. One site in Atp6v1g1 and two in Lpar4 direct degradation of miR-335-3p, showing that in mammals, two sites in the same transcript, and multiple sites in different transcripts, can collaborate to destabilize a microRNA. Moreover, sites in Plagl1 and Lrrc58 direct degradation of miR-322 and miR-503, respectively. Mice lacking the Plagl1 and Lrrc58 sites were smaller, demonstrating that target-directed degradation of miR-322 and miR-503 promotes growth. Both miR-335-3p and Plagl1 are maternally imprinted, implying their participation in parental conflict, but their corresponding triggers or target microRNA partner are not imprinted. Thus, 3¢ UTRs can participate in parental conflict not only by regulating protein production but also directly by engaging TDMD to access an additional layer of regulation within a network of imprinted and biallelic genes.","dates":{"publication":"2026/04/08"},"accession":"GSE318678","cross_references":{"GSM":["GSM9500532","GSM9500554","GSM9500553","GSM9500531","GSM9500530","GSM9500552","GSM9500551","GSM9500550","GSM9500539","GSM9500538","GSM9500559","GSM9500537","GSM9500536","GSM9500558","GSM9500535","GSM9500557","GSM9500556","GSM9500534","GSM9500533","GSM9500555","GSM9500521","GSM9500543","GSM9500565","GSM9500564","GSM9500542","GSM9500541","GSM9500563","GSM9500562","GSM9500540","GSM9500561","GSM9500560","GSM9500529","GSM9500528","GSM9500527","GSM9500549","GSM9500526","GSM9500548","GSM9500547","GSM9500525","GSM9500524","GSM9500546","GSM9500568","GSM9500567","GSM9500523","GSM9500545","GSM9500544","GSM9500566","GSM9500522"],"GPL":["34290"],"GSE":["318678"],"taxon":["Mus musculus"],"PMID":["[41871909]"]}}