GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318772/primaryOK200OtherMus musculusOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318772GEOGSEfalseNew Biologic to Treat Heart Failure Modulates Immune and Stromal Networks for Endogenous RepairChronic heart failure remains a global epidemic without a cure. We report a first-in-class biologic that induces myocardial repair through multiple coordinated pathways including immune cell activation, anti-inflammation, and stromal cell recruitment to promote extracellular matrix (ECM) remodeling. Proteomics reveals a signature enriched in ECM reorganization and immune-modulatory pathways. The biologic acts in a site-specific, biphasic repair program: (1) an initial immune activation phase and (2) resolution characterized by the emergence of TREM2+ reparative macrophages and recruitment of stromal cells. These processes re-establish a regenerative milieu reminiscent of the neonatal heart. By integrating immune, stromal, and cardiomyocyte crosstalk, the biologic establishes a durable pro-reparative microenvironment that restores myocardial structure and function. This immune-guided strategy is a new paradigm for treating chronic ischemic heart failure.2026/04/01GSE318772GSM9502953GSM9503009GSM9503008GSM9502954GSM9502955GSM9502956GSM9502957GSM9502958GSM9502959GSM9503001GSM9503000GSM9503003GSM9503002GSM9503005GSM9503004GSM9502950GSM9502951GSM9503007GSM9502952GSM9503006GSM9502942GSM9502943GSM9502944GSM9502945GSM9502946GSM9502947GSM9502948GSM9502949GSM9502940GSM9502941GSM9502939GSM9502975GSM9502976GSM9502977GSM9502978GSM9502979GSM9502970GSM9502971GSM9502972GSM9502973GSM9502974GSM9503021GSM9503020GSM9502964GSM9503019GSM9502965GSM9502966GSM9502967GSM9502968GSM9502969GSM9503012GSM9503011GSM9503014GSM9503013GSM9503016GSM9502960GSM9503015GSM9502961GSM9502962GSM9503018GSM9503017GSM9502963GSM9503010GSM9502997GSM9502910GSM9502998GSM9502999GSM9502911GSM9502912GSM9502913GSM9502914GSM9502915GSM9502916GSM9502990GSM9502991GSM9502992GSM9502993GSM9502994GSM9502995GSM9502996GSM9502906GSM9502907GSM9502908GSM9502909GSM9502986GSM9502987GSM9502988GSM9502900GSM9502901GSM9502989GSM9502902GSM9502903GSM9502904GSM9502905GSM9502980GSM9502981GSM9502982GSM9502983GSM9502984GSM9502985GSM9502898GSM9502931GSM9502899GSM9502932GSM9502933GSM9502934GSM9502935GSM9502936GSM9502937GSM9502938GSM9502890GSM9502891GSM9502892GSM9502893GSM9502894GSM9502895GSM9502896GSM9502930GSM9502897GSM9502928GSM9502929GSM9502887GSM9502920GSM9502888GSM9502921GSM9502922GSM9502889GSM9502923GSM9502924GSM9502925GSM9502926GSM9502927GSM9502885GSM9502886GSM9502917GSM9502918GSM950291924247318772Mus musculus