{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318796/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318796"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA-seq analysis of B16F10 cells following p300/CBO knockout","description":"The p300 and CBP (CREB-binding protein) paralogs are essential histone acetyltransferases (HATs) that serve as global transcriptional coactivators. In many cancers, including melanoma, these proteins redundantly regulate key oncogenic and lineage-specific gene programs. To investigate their combined role in melanoma, we generated p300/CBP sinlge and double-knockout (dKO) B16F10 murine melanoma cells using CRISPR/Cas9. We then performed bulk RNA-sequencing to identify genes and biological pathways that are critically dependent on these coactivators. Our results define the shared and unique transcriptional targets of p300/CBP in the B16F10 model and provide a resource for understanding how their loss impacts melanoma cell fitness, invasive potential, and stress responses.","dates":{"publication":"2026/04/29"},"accession":"GSE318796","cross_references":{"GSM":["GSM9503416","GSM9503415","GSM9503418","GSM9503417","GSM9503419","GSM9503421","GSM9503420","GSM9503423","GSM9503412","GSM9503422","GSM9503414","GSM9503413"],"GPL":["24247"],"GSE":["318796"],"taxon":["Mus musculus"]}}