{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318836/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318836"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Thyroid Hormone Activation Drives Fibroblast Identity and Tumor Remodeling in Cutaneous Squamous Cell Carcinoma","description":"Cutaneous squamous cell carcinoma (cSCC) is a major cause of cancer-related mortality, with Cancer-Associated Fibroblasts (CAFs) acting as central drivers of tumor progression and immunotherapy resistance. We identified Type 2 deiodinase (D2)-mediated thyroid hormone signaling as a critical regulator of CAF activation. To elucidate the molecular mechanisms governing this reprogramming, we performed RNA-sequencing on CAFs isolated from fibroblast-specific D2 knockout (Col1a2-Cre; D2fl/fl) and wild-type mice (Col1a2-Cre; D2wt/wt). Furthermore, we assessed transcriptional rescue by treating D2-deficient CAFs with exogenous T3. This dataset defines the D2-dependent gene signatures associated with metabolic remodeling and collagen-rich matrix deposition, identifying thyroid hormone signaling as a driver of fibroblast heterogeneity and a potential therapeutic vulnerability in cSCC.","dates":{"publication":"2026/05/24"},"accession":"GSE318836","cross_references":{"GSM":["GSM9504219","GSM9504218","GSM9504220","GSM9504222","GSM9504221","GSM9504224","GSM9504223","GSM9504217","GSM9504216"],"GPL":["34290"],"GSE":["318836"],"taxon":["Mus musculus"]}}