GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318836/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318836GEOGSEfalseThyroid Hormone Activation Drives Fibroblast Identity and Tumor Remodeling in Cutaneous Squamous Cell CarcinomaCutaneous squamous cell carcinoma (cSCC) is a major cause of cancer-related mortality, with Cancer-Associated Fibroblasts (CAFs) acting as central drivers of tumor progression and immunotherapy resistance. We identified Type 2 deiodinase (D2)-mediated thyroid hormone signaling as a critical regulator of CAF activation. To elucidate the molecular mechanisms governing this reprogramming, we performed RNA-sequencing on CAFs isolated from fibroblast-specific D2 knockout (Col1a2-Cre; D2fl/fl) and wild-type mice (Col1a2-Cre; D2wt/wt). Furthermore, we assessed transcriptional rescue by treating D2-deficient CAFs with exogenous T3. This dataset defines the D2-dependent gene signatures associated with metabolic remodeling and collagen-rich matrix deposition, identifying thyroid hormone signaling as a driver of fibroblast heterogeneity and a potential therapeutic vulnerability in cSCC.2026/05/24GSE318836GSM9504219GSM9504218GSM9504220GSM9504222GSM9504221GSM9504224GSM9504223GSM9504217GSM950421634290318836Mus musculus