GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318882/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318882GEOGSEfalseA complex mutational signature generated by cytarabine resistanceT cell acute lymphoblastic leukemia (T-ALL) patients generally respond well to chemotherapy, but T-ALL cells at relapse are typically resistant to chemotherapy. The specific mechanisms leading to chemoresistance are incompletely understood. Here we use Mcm2 hypomorph (Mcm2hypo) T-ALL cell lines, which are prone to copy number variant mutations, to identify acquired mutations that underlie chemoresistance. We successfully generated 11 chemotherapy-resistant T-ALL cell lines, identifying excellent candidate genes responsible for resistance due to acquired mutations, including CNV, SNV, and small indels.These candidates included amplification of Abcb1a/b associated with vincristine resistance, amplification of Dhfr associated with methotrexate resistance, loss of Nr3c1 associated with prednisone resistance and loss of Dck associated with cytarabine resistance.2026/04/01GSE318882GSM9505455GSM9505456GSM9505453GSM9505454GSM9505459GSM9505448GSM9505449GSM9505457GSM9505447GSM9505458GSM9505462GSM9505451GSM9505452GSM9505460GSM9505461GSM950545030172318882Mus musculus