{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318951/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318951"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic profiling of neonatal mouse ventricular myocytes (NMVMs) under hypoxia and recombinant Serglycin stimulation","description":"To investigate the direct regulatory effects of Serglycin (SRGN) on cardiomyocytes under ischemic conditions, we performed bulk RNA-sequencing on primary neonatal mouse ventricular myocytes (NMVMs). The study includes three experimental groups: Control (Con), Hypoxia, and Hypoxia + recombinant SRGN (rSRGN). NMVMs in the Hypoxia and Hypoxia+rSRGN groups were subjected to oxygen-glucose deprivation (glucose-free and serum-free DMEM) in an anaerobic environment (AnaeroPack-MIC, Mitsubishi A-07) for 6 hours. This dataset identifies the transcriptional alterations driven by SRGN in cardiomyocytes during hypoxic stress.","dates":{"publication":"2026/06/25"},"accession":"GSE318951","cross_references":{"GSM":["GSM9506805","GSM9506803","GSM9506804","GSM9506797","GSM9506798","GSM9506801","GSM9506802","GSM9506799","GSM9506800"],"GPL":["24247"],"GSE":["318951"],"taxon":["Mus musculus"],"PMID":["[42327787]"]}}