{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319183"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Dynamic expression of CD9 protein in T-cell acute lymphoblastic leukemia [bulk RNA-seq]","description":"T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy affecting both children and adults. Given its persistently poor prognosis, there is a critical need to identify additional factors involved in T-ALL oncogenesis and progression. CD9, a membrane protein of the tetraspanin family implicated in diverse cellular processes, has been associated with prognosis in several cancers, yet its role in T-ALL remains poorly understood. In this study, using first a mouse model, we found that CD9 overexpression is associated with leukemic T cells that have migrated outside the thymus into peripheral tissues. Then, analysis of a human T-ALL cohort shows that CD9 expression is heterogeneous, tends to increase at relapse and is enriched in the TAL1⁺ molecular subtype. We further demonstrate that CD9⁺ cells display enhanced migratory capacity compared with CD9⁻ counterparts, and that CD9 levels affect extracellular vesicle biogenesis. Altogether our findings support a role for CD9 in T-ALL leukemogenesis and highlight its potential involvement in relapse.","dates":{"publication":"2026/04/27"},"accession":"GSE319183","cross_references":{"GSM":["GSM9513248","GSM9513247","GSM9513246","GSM9513245","GSM9513244","GSM9513243","GSM9513242","GSM9513252","GSM9513241","GSM9513251","GSM9513250","GSM9513249"],"GPL":["34281"],"GSE":["319183"],"taxon":["Homo sapiens"]}}