GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319199/primary200OKTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319199GEOGSEfalseComprehensive Cytogenetic and Genomic Profiling of the Murine AML12 (Alpha Mouse Liver 12) Hepatocyte Cell LineIn our study, we aimed to provide a comprehensive cytogenetic and genomic profiling of the murine AML12 hepatocyte cell line. We established an integrated reference map that combines cytogenetics, short tandem repeat (STR) profiling, and transcriptomic analysis through RNA sequencing. Our findings reveal that AML12 maintains hepatocyte lineage identity while exhibiting partial de-differentiation and a complex karyotypic landscape characterized by a near-tetraploid chromosome set with recurrent structural rearrangements. This study serves as a valuable resource for the scientific community, enhancing the understanding of AML12's genetic characteristics and its implications for future research in liver biology and related fields.2026/06/15GSE319199GSM951338516417319199Mus musculus[41827824]