{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319298/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319298"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"H3K27ac CUT&Tag profiling of kidney allograft - infiltrating and matched PBMC CD8+ T cells","description":"Kidney allograft rejection is associated with infiltrating cytotoxic CD8+ T cells that exhibit distinct functional and transcriptional programs compared with circulating T cells in the peripheral blood. However, the epigenetic mechanisms underlying these tissue-specific effector states in human transplantation remain incompletely understood. Here, we performed H3K27ac CUT&Tag profiling on CD8+ T cells isolated from rejected human kidney allografts and matched peripheral blood mononuclear cells (PBMCs). Comparative analyses revealed distinct H3K27ac enrichment patterns at loci associated with cytotoxic effector programs in allograft-infiltrating CD8+ T cells relative to matched circulating CD8+ T cells. These data provide a resource for dissecting epigenetic programs that shape pathogenic CD8+ T cell responses during human kidney allograft rejection.","dates":{"publication":"2026/09/21"},"accession":"GSE319298","cross_references":{"GSM":["GSM9515015","GSM9515016"],"GPL":["24676"],"GSE":["319298"],"taxon":["Homo sapiens"]}}