{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319303/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319303"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Bulk ATAC-seq of young HSCs and Selp high vs Selp low HSCs in pre-aged mice","description":"Aging of hematopoietic stem cells (HSCs) is accompanied by changes in chromatin organization that precede and shape functional decline. P-selectin (Selp/CD62P) expression has been associated with inflammatory and stress-related hematopoietic states, yet how Selp expression relates to chromatin accessibility during the early stages of HSC aging remains largely unexplored. To address this, we performed bulk ATAC-seq on phenotypically defined HSCs isolated from young mice and from pre-aged mice, with the latter further subdivided according to surface Selp expression (Selp_high and Selp_low). Genome-wide accessibility profiling was used to identify regulatory elements and transcription factor–associated regions that distinguish early aging and Selp-associated heterogeneity within the HSC compartment. These data provide a resource for investigating epigenetic remodeling and regulatory priming associated with early hematopoietic stem cell aging.","dates":{"publication":"2026/07/06"},"accession":"GSE319303","cross_references":{"GSM":["GSM9515070","GSM9515071","GSM9515072","GSM9515073","GSM9515074","GSM9515075","GSM9515076","GSM9515068","GSM9515069"],"GPL":["34290"],"GSE":["319303"],"taxon":["Mus musculus"]}}