GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319303/primary200OKGenomicsMus musculusGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319303GEOGSEfalseBulk ATAC-seq of young HSCs and Selp high vs Selp low HSCs in pre-aged miceAging of hematopoietic stem cells (HSCs) is accompanied by changes in chromatin organization that precede and shape functional decline. P-selectin (Selp/CD62P) expression has been associated with inflammatory and stress-related hematopoietic states, yet how Selp expression relates to chromatin accessibility during the early stages of HSC aging remains largely unexplored. To address this, we performed bulk ATAC-seq on phenotypically defined HSCs isolated from young mice and from pre-aged mice, with the latter further subdivided according to surface Selp expression (Selp_high and Selp_low). Genome-wide accessibility profiling was used to identify regulatory elements and transcription factor–associated regions that distinguish early aging and Selp-associated heterogeneity within the HSC compartment. These data provide a resource for investigating epigenetic remodeling and regulatory priming associated with early hematopoietic stem cell aging.2026/07/06GSE319303GSM9515070GSM9515071GSM9515072GSM9515073GSM9515074GSM9515075GSM9515076GSM9515068GSM951506934290319303Mus musculus