{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319489/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319489"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging","description":"Single-cell RNA sequencing of sorted mouse liver cells from young (6-8 month) and aged (23-25 month) Cx3cr1CreER;EP2wt/wt (WT) and Cx3cr1CreER;EP2lox/lox (EP2 cKO) male mice. Liver cells were enzymatically dissociated and live CD45+, CD1d+, or CD31+ cells were FACS-sorted in a 1:1:1 ratio, then processed using the 10x Genomics Chromium X platform (Next GEM Single Cell 3' Gene Expression). This dataset supports the finding that tissue-resident macrophage (TRM)-selective EP2 (PTGER2) deletion restores efferocytic clearance of senescent neutrophils and reverses age-associated transcriptional programs in Kupffer cells, preventing multi-organ aging phenotypes.","dates":{"publication":"2026/07/16"},"accession":"GSE319489","cross_references":{"GSM":["GSM9518591","GSM9518590","GSM9518593","GSM9518592","GSM9518586","GSM9518588","GSM9518587","GSM9518589"],"GPL":["34328"],"GSE":["319489"],"taxon":["Mus musculus"]}}