{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319552/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Sus scrofa"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319552"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Ketone and glycolytic metabolism are key modulators of inflammation during neonatal sepsis","description":"Neonatal sepsis is a life-threatening condition in preterm infants, primarily due to a dysregulated immunometabolic response to infection. Sepsis and infection mortality are associated with excessive glycolysis-induced inflammation, impaired mitochondrial oxidative phosphorylation (OXPHOS) and loss of disease tolerance. Reduced glucose intake can reverse these dysregulations, but it is unclear how the mechanistic control of glycolysis-OXPHOS balance drives defense strategies and infection outcomes. Here, in a preterm piglet model of neonatal sepsis, glycolysis inhibition with 2-deoxyglucose (2-DG) completely prevents acute infection mortality, reduces systemic inflammation and markers of liver injury, accompanied by enhanced mitochondrial metabolism and disease tolerance. Strikingly, this protection by 2-DG is conferred despite elevated blood glucose levels and higher bacterial burdens than the infected controls. Alternatively, partial replacement of glucose intake with the ketone beta-hydroxybutyrate (BHB) abolishes sepsis-related mortality via improving disease tolerance and clinical parameters.","dates":{"publication":"2026/02/16"},"accession":"GSE319552","cross_references":{"GSM":["GSM9519692","GSM9519693","GSM9519690","GSM9519691","GSM9519696","GSM9519697","GSM9519730","GSM9519694","GSM9519695","GSM9519719","GSM9519717","GSM9519718","GSM9519711","GSM9519733","GSM9519712","GSM9519731","GSM9519698","GSM9519732","GSM9519699","GSM9519710","GSM9519715","GSM9519716","GSM9519713","GSM9519714","GSM9519686","GSM9519708","GSM9519709","GSM9519706","GSM9519728","GSM9519729","GSM9519707","GSM9519689","GSM9519700","GSM9519722","GSM9519723","GSM9519701","GSM9519720","GSM9519687","GSM9519688","GSM9519721","GSM9519726","GSM9519704","GSM9519705","GSM9519727","GSM9519702","GSM9519724","GSM9519703","GSM9519725"],"GPL":["26351"],"GSE":["319552"],"taxon":["Sus scrofa"]}}