GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319664/primary200OKTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319664GEOGSEfalseRNA-seq analysis of tumors derived from a xenograft model treated with the KDM5B inhibitors JB-157 or JB-161.KDM5B, a member of the KDM5 family of histone demethylases, functions as a key epigenetic regulator by removing di- and trimethyl groups from H3K4 (H3K4me2/3), thereby promoting transcriptional repression. It is involved in fundamental biological processes, including development, stem cell maintenance, and tumorigenesis, and its dysregulation has been associated with multiple cancer types. Given its critical role in cancer biology, KDM5B has emerged as an attractive target for therapeutic intervention. Therefore, we conducted a screening campaign to identify novel KDM5B inhibitors. In this study, we investigated whether the KDM5B inhibitors JB-157 and JB-161, identified through our screening, exert antitumor effects.2026/07/01GSE319664GSM9523157GSM9523156GSM9523159GSM9523158GSM9523153GSM9523152GSM9523155GSM9523154GSM9523171GSM9523170GSM9523151GSM9523150GSM9523172GSM9523168GSM9523146GSM9523167GSM9523145GSM9523148GSM9523147GSM9523169GSM9523164GSM9523163GSM9523144GSM9523166GSM9523165GSM9523149GSM9523160GSM9523162GSM952316134284319664Homo sapiens[42324589]