{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319777/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Homo sapiens"],"gds_type":["Methylation profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319777"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Therapeutic TG2 Inhibition Reverses Systemic Multiomic Dysregulation in Celiac Disease","description":"Background and Aims: Celiac disease (CeD) is an autoimmune disease triggered by dietary gluten in genetically predisposed individuals. Deamidation of gluten peptides by the CeD autoantigen and enzyme transglutaminase 2 (TG2) is central to the pathogenesis of CeD. Inhibition of TG2 with the specific inhibitor ZED1227 effectively prevents gluten-induced histological damage in CeD patients. Here we aimed to explore the blood DNA methylomic changes in ZED1227-treated CeD patients undergoing a gluten challenge. Results: Drug treatment revealed consistent patterns suggesting normalization of the DNA methylome indicating that ZED1227 attenuated the systemic responses to gluten challenge. Conclusions: These findings provide evidence that ZED1227 can significantly prevent the gluten-induced CeD-associated systemic changes. Clinical trial: EudraCT 2017-002241-30","dates":{"publication":"2026/06/18"},"accession":"GSE319777","cross_references":{"GSM":["GSM9526249","GSM9526205","GSM9526206","GSM9526203","GSM9526247","GSM9526248","GSM9526204","GSM9526245","GSM9526201","GSM9526246","GSM9526202","GSM9526243","GSM9526200","GSM9526244","GSM9526209","GSM9526207","GSM9526208","GSM9526241","GSM9526242","GSM9526240","GSM9526216","GSM9526217","GSM9526214","GSM9526215","GSM9526212","GSM9526213","GSM9526210","GSM9526211","GSM9526218","GSM9526219","GSM9526252","GSM9526253","GSM9526250","GSM9526251","GSM9526227","GSM9526228","GSM9526225","GSM9526226","GSM9526223","GSM9526224","GSM9526188","GSM9526221","GSM9526189","GSM9526222","GSM9526229","GSM9526186","GSM9526220","GSM9526187","GSM9526184","GSM9526185","GSM9526182","GSM9526183","GSM9526238","GSM9526239","GSM9526236","GSM9526237","GSM9526234","GSM9526235","GSM9526232","GSM9526199","GSM9526233","GSM9526190","GSM9526197","GSM9526230","GSM9526231","GSM9526198","GSM9526195","GSM9526196","GSM9526193","GSM9526194","GSM9526191","GSM9526192"],"GPL":["33022"],"GSE":["319777"],"taxon":["Homo sapiens"],"PMID":["[42032651]"]}}