{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319793/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319793"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Drug-seq analysis of adult T-cell leukemia cells treated with fluorouracil and bleomycin","description":"Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy that develops in a subset of individuals infected with human T-lymphotropic virus type 1 (HTLV-1) and is characterized by marked chemoresistance and frequent relapse. HTLV-1 preferentially infects CD4⁺ T cells, which constitute the main malignant population in ATL. We evaluated transcriptomic perturbations in CD4⁺ T cells from five ATL patients, three healthy donors, and two ATL cell lines following 48-hour treatment with the chemotherapeutic agents fluorouracil and bleomycin sulfate.","dates":{"publication":"2026/09/09"},"accession":"GSE319793","cross_references":{"GSM":["GSM9526451"],"GPL":["34295"],"GSE":["319793"],"taxon":["Homo sapiens"]}}