{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319859/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319859"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA-seq profiling of cerebral organoids derived from CBP mutant iPSCs","description":"CREB-binding protein (CBP/CREBBP) is a histone acetyltransferase essential for human development. Mutations in CBP are associated with Menke–Hennekam syndrome (MKHK), a neurodevelopmental disorder. To examine the impact of a disease-associated mutation, we performed RNA sequencing on cerebral organoids derived from isogenic wild-type and CBP R1868 mutant human induced pluripotent stem cells (iPSCs) at Day6, Day12, Day18 and Day30 of differentiation. This time-course RNA-seq data captures gene expression programs during early neurodevelopment and reveals how the CBP R1868W mutation influences transcriptional states in human cerebral organoids.","dates":{"publication":"2026/04/21"},"accession":"GSE319859","cross_references":{"GSM":["GSM9527933","GSM9527932","GSM9527931","GSM9527930","GSM9527919","GSM9527918","GSM9527939","GSM9527917","GSM9527938","GSM9527937","GSM9527936","GSM9527935","GSM9527934","GSM9527922","GSM9527944","GSM9527921","GSM9527943","GSM9527942","GSM9527920","GSM9527941","GSM9527940","GSM9527929","GSM9527928","GSM9527927","GSM9527926","GSM9527925","GSM9527924","GSM9527923"],"GPL":["34295"],"GSE":["319859"],"taxon":["Homo sapiens"]}}