GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319859/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319859GEOGSEfalseRNA-seq profiling of cerebral organoids derived from CBP mutant iPSCsCREB-binding protein (CBP/CREBBP) is a histone acetyltransferase essential for human development. Mutations in CBP are associated with Menke–Hennekam syndrome (MKHK), a neurodevelopmental disorder. To examine the impact of a disease-associated mutation, we performed RNA sequencing on cerebral organoids derived from isogenic wild-type and CBP R1868 mutant human induced pluripotent stem cells (iPSCs) at Day6, Day12, Day18 and Day30 of differentiation. This time-course RNA-seq data captures gene expression programs during early neurodevelopment and reveals how the CBP R1868W mutation influences transcriptional states in human cerebral organoids.2026/04/21GSE319859GSM9527933GSM9527932GSM9527931GSM9527930GSM9527919GSM9527918GSM9527939GSM9527917GSM9527938GSM9527937GSM9527936GSM9527935GSM9527934GSM9527922GSM9527944GSM9527921GSM9527943GSM9527942GSM9527920GSM9527941GSM9527940GSM9527929GSM9527928GSM9527927GSM9527926GSM9527925GSM9527924GSM952792334295319859Homo sapiens