{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE320nnn/GSE320158/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE320158"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"NCOR2 represses MHC class I molecule expression to drive metastatic progression of breast cancer","description":"Metastatic progression depends upon the ability of disseminated tumor cells to evade immune surveillance. MHC-mediated antigen presentation facilitates T cell-dependent eradication of metastatic tumor cells. We identified nuclear corepressor 2 (NCOR2) as an epigenetic regulator of MHC class I molecule presentation on breast tumor cells. Patients with triple negative breast cancers (TNBC) that expressed high levels of NCOR2 also exhibited reduced metastasis-free survival and decreased MHC class I expression, and metastatic lesions in patients with TNBC had high nuclear NCOR2 and reduced CD8+ T cells. Reducing NCOR2 expression or preventing its interaction with HDAC3 enhanced innate immune cell recruitment and activity, and elevated MHC class I levels on disseminated cancer cells to potentiate CD8+ T cell activity and apoptosis induction that prevented metastatic progression. The studies provide evidence to support NCOR2 as a targetable epigenetic regulator of metastasis towards which therapies could be developed to reduce patient mortality.","dates":{"publication":"2026/07/15"},"accession":"GSE320158","cross_references":{"GSM":["GSM9535894","GSM9535895","GSM9535896","GSM9535897","GSM9535890","GSM9535891","GSM9535892","GSM9535893","GSM9535902","GSM9535898","GSM9535899","GSM9535900","GSM9535889","GSM9535901"],"GPL":["34328"],"GSE":["320158"],"taxon":["Mus musculus"],"PMID":["[42086546]"]}}