{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE320nnn/GSE320190/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE320190"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"High-Dose Vitamin D3 Supplementation Associates with Innate Immune Chromatin Remodeling and Context-Dependent Transcriptomic Responses in Multiple Sclerosis [RNA-seq]","description":"We performed longitudinal RNA-seq and ATAC-seq profiling of PBMCs from multiple sclerosis patients receiving vitamin D₃ supplementation for day 0 and day 84. MS samples remained molecularly distinct from controls, with supplementation modulating discrete, context-dependent immune pathways rather than inducing global transcriptomic shifts. Integrated analysis identified candidate vitamin D–responsive regulatory mechanisms with potential relevance to MS pathophysiology.","dates":{"publication":"2026/08/24"},"accession":"GSE320190","cross_references":{"GSM":["GSM9537042","GSM9537064","GSM9537063","GSM9537066","GSM9537044","GSM9537043","GSM9537065","GSM9537060","GSM9537062","GSM9537061","GSM9537049","GSM9537046","GSM9537068","GSM9537045","GSM9537067","GSM9537048","GSM9537069","GSM9537047","GSM9537075","GSM9537053","GSM9537052","GSM9537074","GSM9537055","GSM9537054","GSM9537071","GSM9537070","GSM9537051","GSM9537073","GSM9537072","GSM9537050","GSM9537057","GSM9537056","GSM9537059","GSM9537058"],"GPL":["18573"],"GSE":["320190"],"taxon":["Homo sapiens"],"PMID":["[42601952]"]}}