GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE320nnn/GSE320190/primary200OKTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE320190GEOGSEfalseHigh-Dose Vitamin D3 Supplementation Associates with Innate Immune Chromatin Remodeling and Context-Dependent Transcriptomic Responses in Multiple Sclerosis [RNA-seq]We performed longitudinal RNA-seq and ATAC-seq profiling of PBMCs from multiple sclerosis patients receiving vitamin D₃ supplementation for day 0 and day 84. MS samples remained molecularly distinct from controls, with supplementation modulating discrete, context-dependent immune pathways rather than inducing global transcriptomic shifts. Integrated analysis identified candidate vitamin D–responsive regulatory mechanisms with potential relevance to MS pathophysiology.2026/08/24GSE320190GSM9537042GSM9537064GSM9537063GSM9537066GSM9537044GSM9537043GSM9537065GSM9537060GSM9537062GSM9537061GSM9537049GSM9537046GSM9537068GSM9537045GSM9537067GSM9537048GSM9537069GSM9537047GSM9537075GSM9537053GSM9537052GSM9537074GSM9537055GSM9537054GSM9537071GSM9537070GSM9537051GSM9537073GSM9537072GSM9537050GSM9537057GSM9537056GSM9537059GSM953705818573320190Homo sapiens[42601952]