{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE320nnn/GSE320191/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE320191"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"High-Dose Vitamin D3 Supplementation Associates with Innate Immune Chromatin Remodeling and Context-Dependent Transcriptomic Responses in Multiple Sclerosis [ATAC-seq]","description":"We performed longitudinal RNA-seq and ATAC-seq profiling of PBMCs from multiple sclerosis patients receiving vitamin D₃ supplementation for day 0 and day 84. MS samples remained molecularly distinct from controls, with supplementation modulating discrete, context-dependent immune pathways rather than inducing global transcriptomic shifts. Integrated analysis identified candidate vitamin D–responsive regulatory mechanisms with potential relevance to MS pathophysiology.","dates":{"publication":"2026/08/24"},"accession":"GSE320191","cross_references":{"GSM":["GSM9537080","GSM9537091","GSM9537090","GSM9537086","GSM9537085","GSM9537077","GSM9537088","GSM9537087","GSM9537076","GSM9537093","GSM9537082","GSM9537092","GSM9537081","GSM9537095","GSM9537084","GSM9537083","GSM9537094","GSM9537079","GSM9537078","GSM9537089"],"GPL":["18573"],"GSE":["320191"],"taxon":["Homo sapiens"],"PMID":["[42601952]"]}}