GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE320nnn/GSE320191/primaryOK200GenomicsHomo sapiensGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE320191GEOGSEfalseHigh-Dose Vitamin D3 Supplementation Associates with Innate Immune Chromatin Remodeling and Context-Dependent Transcriptomic Responses in Multiple Sclerosis [ATAC-seq]We performed longitudinal RNA-seq and ATAC-seq profiling of PBMCs from multiple sclerosis patients receiving vitamin D₃ supplementation for day 0 and day 84. MS samples remained molecularly distinct from controls, with supplementation modulating discrete, context-dependent immune pathways rather than inducing global transcriptomic shifts. Integrated analysis identified candidate vitamin D–responsive regulatory mechanisms with potential relevance to MS pathophysiology.2026/08/24GSE320191GSM9537080GSM9537091GSM9537090GSM9537086GSM9537085GSM9537077GSM9537088GSM9537087GSM9537076GSM9537093GSM9537082GSM9537092GSM9537081GSM9537095GSM9537084GSM9537083GSM9537094GSM9537079GSM9537078GSM953708918573320191Homo sapiens[42601952]