{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE320nnn/GSE320260/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Oryctolagus cuniculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE320260"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single-nucleus transcriptomics of CLRN1 knockout rabbit retina reveals Müller glia-driven mechanisms of retinal degeneration","description":"Single-nucleus RNA sequencing of wild-type and CLRN1 knockout rabbit retina at 10 months of age (pre-symptomatic timepoint). Three biological replicates per genotype were pooled and processed using 10x Genomics Chromium Single Cell 3' v3.1 platform. SNP-based demultiplexing with Vireo was used to assign nuclei to individual animals. Analysis of 6,542 high-quality nuclei across 7 retinal cell types revealed that CLRN1 is exclusively expressed in Müller glia and identified a primary adherens junction defect (CTNNA2 downregulation) leading to secondary photoreceptor degeneration while inner retinal neurons mount robust compensatory responses.","dates":{"publication":"2026/07/08"},"accession":"GSE320260","cross_references":{"GSM":["GSM9538438","GSM9538439"],"GPL":["35700"],"GSE":["320260"],"taxon":["Oryctolagus cuniculus"],"PMID":["[42390169]"]}}