GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE320nnn/GSE320260/primaryOK200TranscriptomicsOryctolagus cuniculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE320260GEOGSEfalseSingle-nucleus transcriptomics of CLRN1 knockout rabbit retina reveals Müller glia-driven mechanisms of retinal degenerationSingle-nucleus RNA sequencing of wild-type and CLRN1 knockout rabbit retina at 10 months of age (pre-symptomatic timepoint). Three biological replicates per genotype were pooled and processed using 10x Genomics Chromium Single Cell 3' v3.1 platform. SNP-based demultiplexing with Vireo was used to assign nuclei to individual animals. Analysis of 6,542 high-quality nuclei across 7 retinal cell types revealed that CLRN1 is exclusively expressed in Müller glia and identified a primary adherens junction defect (CTNNA2 downregulation) leading to secondary photoreceptor degeneration while inner retinal neurons mount robust compensatory responses.2026/07/08GSE320260GSM9538438GSM953843935700320260Oryctolagus cuniculus[42390169]