{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE320nnn/GSE320421/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE320421"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Hydroxychloroquine Alleviates Cyclophosphamide-Induced Premature Ovarian Failure by Attenuating Granulosa Cell Senescence and Modulating the mtDNA-cGAS Pathway","description":"Cyclophosphamide (CTX) is a first-line chemotherapeutic agent for various cancers but is associated with a significant risk of ovarian dysfunction, which may even progress to premature ovarian failure (POF). Granulosa cell senescence is a key phenotypic manifestation of this process. Hydroxychloroquine (HCQ) exerts anti-senescence effects in age-related diseases; however, its efficacy in preventing CTX-induced ovarian damage remains elusive. We aimed to verify the protective effect of HCQ using a CTX-induced POF mouse model.","dates":{"publication":"2026/05/15"},"accession":"GSE320421","cross_references":{"GSM":["GSM9542837","GSM9542836","GSM9542839","GSM9542838","GSM9542840","GSM9542833","GSM9542832","GSM9542835","GSM9542834"],"GPL":["24247"],"GSE":["320421"],"taxon":["Mus musculus"],"PMID":["[41839900]"]}}