GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE320nnn/GSE320421/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE320421GEOGSEfalseHydroxychloroquine Alleviates Cyclophosphamide-Induced Premature Ovarian Failure by Attenuating Granulosa Cell Senescence and Modulating the mtDNA-cGAS PathwayCyclophosphamide (CTX) is a first-line chemotherapeutic agent for various cancers but is associated with a significant risk of ovarian dysfunction, which may even progress to premature ovarian failure (POF). Granulosa cell senescence is a key phenotypic manifestation of this process. Hydroxychloroquine (HCQ) exerts anti-senescence effects in age-related diseases; however, its efficacy in preventing CTX-induced ovarian damage remains elusive. We aimed to verify the protective effect of HCQ using a CTX-induced POF mouse model.2026/05/15GSE320421GSM9542837GSM9542836GSM9542839GSM9542838GSM9542840GSM9542833GSM9542832GSM9542835GSM954283424247320421Mus musculus[41839900]