GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE320nnn/GSE320478/primaryOK200TranscriptomicsPhodopus sungorusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE320478GEOGSEfalseThe transcriptional cortical adaptations to daily torpor in Phodopus sungorusTorpor is an essential evolutionary strategy that allows mammals to conserve resources under extreme environmental conditions. While the hypothalamus is a key regulator of systemic adaptations to energy scarcity and reduced temperature, it remains unclear how the cortex, with its high metabolic demand, endures this state. Here, we performed RNA sequencing on neuronal and non-neuronal nuclei isolated from the cortex of Djungarian hamsters (Phodopus sungorus) across different seasonal and metabolic states. We found that non-neuronal cells primarily adapt during the seasonal transition from summer to winter phenotype, with differential expression of genes linked to circadian rhythm. In contrast, cortical neurons exhibited major transcriptional changes only between normothermia and hypothermia, marked by increased expression of RNA catabolic pathways. Finally, comparison with published hypothalamic datasets revealed distinct transcriptional programs between the cortex and hypothalamus. Together, these findings highlight cell type- and region-specific adaptations that preserve CNS integrity during metabolic depression.2026/06/01GSE320478GSM9543960GSM9543940GSM9543942GSM9543941GSM9543944GSM9543943GSM9543946GSM9543945GSM9543937GSM9543959GSM9543936GSM9543958GSM9543939GSM9543938GSM9543951GSM9543950GSM9543953GSM9543952GSM9543955GSM9543954GSM9543957GSM9543935GSM9543956GSM9543948GSM9543947GSM954394936646320478Phodopus sungorus