{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE322nnn/GSE322779/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE322779"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcription factor TFEB antagonizes cardiac hypertrophy and failure by enhancing lysosomal capacity and mitochondrial function","description":"Pathological cardiac remodeling and increased afterload-driven demand contribute to heart failure. TFEB is a key regulator of lysosomal genes and mitochondrial function and is activated in response to external stress. To elucidate TFEB-dependent transcriptional programs under hypertrophic stress, we profiled left ventricular transcriptomes from a cardiomyocyte-specific TFEB knockout mouse model subjected to transverse aortic constriction (TAC) or sham surgery, with wild-type littermate controls, followed by downstream multi-omics integration.","dates":{"publication":"2026/05/11"},"accession":"GSE322779","cross_references":{"GSM":["GSM9558311","GSM9558310","GSM9558313","GSM9558302","GSM9558312","GSM9558315","GSM9558304","GSM9558303","GSM9558314","GSM9558306","GSM9558317","GSM9558316","GSM9558305","GSM9558308","GSM9558307","GSM9558309"],"GPL":["24247"],"GSE":["322779"],"taxon":["Mus musculus"]}}