GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE323nnn/GSE323364/primaryOK200GenomicsHomo sapiensGenome binding/occupancy profiling by high throughput sequencing Expression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE323364GEOGSEfalseCoordinating catalytic and non-canonical functions of EZH2 sensitizes tumors to CAR-T cell therapyThis study investigates the dual roles of EZH2 (catalytic and non-canonical) in regulating tumor cell adhesion and sensitivity to CAR-T cell therapy. We performed RNA-seq and CUT&Tag-seq (anti-EZH2) on three human triple-negative breast cancer cell lines (MDA-MB-436, MDA-MB-468, HCC1806) treated with the EZH2 inhibitor EPZ-6438. Additionally, RNA-seq was performed on MDA-MB-468 cells with EZH2 knockdown to dissect the EZH2-dependent transcriptomic underlying tumor cell adhesion and CAR-T therapy response.2026/05/21GSE323364GSM9564368GSM9564369GSM9564388GSM9564366GSM9564367GSM9564389GSM9564364GSM9564386GSM9564387GSM9564365GSM9564384GSM9564362GSM9564385GSM9564363GSM9564382GSM9564360GSM9564361GSM9564383GSM9564380GSM9564381GSM9564390GSM9564359GSM9564379GSM9564358GSM9564399GSM9564377GSM9564378GSM9564397GSM9564375GSM9564376GSM9564398GSM9564373GSM9564395GSM9564396GSM9564374GSM9564393GSM9564371GSM9564394GSM9564372GSM9564391GSM9564370GSM956439220301323364Homo sapiens