{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324594/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324594"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic changes in primary human keratinocytes following exposure to lamotrigine, lamotrigine-N2-oxide, lamotrigine in combination with valproic acid or interferon-γ, and interferon-γ alone","description":"Bulk RNA sequencing with differential expression analysis was used to examine transcriptional changes in keratinocytes after exposure to lamotrigine (LTG), its CYP-mediated metabolite LTG-N2-oxide, and co-incubated LTG with valproic acid (VPA). IFN-γ served as a positive control, as its effects on keratinocytes are well documented.","dates":{"publication":"2026/03/30"},"accession":"GSE324594","cross_references":{"GSM":["GSM9579959","GSM9579957","GSM9579958","GSM9579977","GSM9579955","GSM9579956","GSM9579953","GSM9579975","GSM9579976","GSM9579954","GSM9579973","GSM9579951","GSM9579974","GSM9579952","GSM9579971","GSM9579972","GSM9579950","GSM9579970","GSM9579948","GSM9579949","GSM9579968","GSM9579946","GSM9579969","GSM9579947","GSM9579966","GSM9579944","GSM9579945","GSM9579967","GSM9579942","GSM9579964","GSM9579965","GSM9579943","GSM9579962","GSM9579963","GSM9579960","GSM9579961"],"GPL":["24676"],"GSE":["324594"],"taxon":["Homo sapiens"],"PMID":["[41910223]"]}}