{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324598/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Caenorhabditis elegans"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324598"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA-seq analysis of Caenorhabditis elegans treated with Lycii Fructus polysaccharide (FSP)","description":"Lycii Fructus polysaccharides are widely reported to possess anti-aging and cytoprotective properties, but the molecular mechanisms underlying their effects on mitochondrial homeostasis remain unclear.RNA sequencing was performed to investigate transcriptomic changes in Caenorhabditis elegans treated with a purified Lycii Fructus polysaccharide fraction (FSP). Differential expression and pathway enrichment analyses revealed significant activation of mitochondrial unfolded protein response (UPRmt) and longevity-associated pathways, suggesting that FSP promotes mitochondrial homeostasis and stress resilience during aging.","dates":{"publication":"2026/09/02"},"accession":"GSE324598","cross_references":{"GSM":["GSM9580020","GSM9580021","GSM9580022","GSM9580023","GSM9580018","GSM9580019"],"GPL":["34620"],"GSE":["324598"],"taxon":["Caenorhabditis elegans"],"PMID":["[42650207]"]}}