GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324598/primaryOK200TranscriptomicsCaenorhabditis elegansExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324598GEOGSEfalseRNA-seq analysis of Caenorhabditis elegans treated with Lycii Fructus polysaccharide (FSP)Lycii Fructus polysaccharides are widely reported to possess anti-aging and cytoprotective properties, but the molecular mechanisms underlying their effects on mitochondrial homeostasis remain unclear.RNA sequencing was performed to investigate transcriptomic changes in Caenorhabditis elegans treated with a purified Lycii Fructus polysaccharide fraction (FSP). Differential expression and pathway enrichment analyses revealed significant activation of mitochondrial unfolded protein response (UPRmt) and longevity-associated pathways, suggesting that FSP promotes mitochondrial homeostasis and stress resilience during aging.2026/09/02GSE324598GSM9580020GSM9580021GSM9580022GSM9580023GSM9580018GSM958001934620324598Caenorhabditis elegans[42650207]