GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324651/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324651GEOGSEfalseNeutrophils Orchestrate Osteoclastogenesis in Orthodontic Tooth MovementTo elucidate the biological mechanisms of alveolar bone remodeling during orthodontic tooth movement (OTM), we performed single-cell RNA sequencing (scRNA-seq) on periodontal ligament (PDL) tissues from a mouse OTM model. We identified 11 distinct cell clusters and revealed that neutrophils are a primary source of pro-inflammatory cytokines such as TNF, IL-1β, and OSM. Our analysis identified a specific “Inflammatory-Neu” subset that expands during OTM and coordinates macrophage recruitment. This study demonstrates that neutrophils act as indispensable upstream regulators that drive osteoclastogenesis during mechanical loading.2026/07/10GSE324651GSM9581652GSM958165324247324651Mus musculus