{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324656/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324656"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Magnetically Actuated Nanoantennas for Wireless Glioblastoma Therapy","description":"Glioblastoma (GBM) remains a formidable clinical challenge, characterized by invasive growth, therapeutic resistance and dismal patient survival. We report the development of HITMAN (Highly-localized-electric-field Induced Tumor-therapy using Magnetically Actuated Nanoantennas), a wireless bioelectric therapy that selectively eradicates GBM cells with cellular precision. Magnetically actuated nanoantennas convert low-frequency (≤200 kHz), deep-brain penetrant magnetic fields into localized electric fields (>2 kV m⁻¹), triggering protein unfolding, membrane disruption, and ER stress. In vitro, HITMAN demonstrated superior efficacy compared to temozolomide (TMZ), significantly decreasing viability in drug-resistant, patient-derived GBM cells by 52.2%, versus 10% with TMZ, while sparing neurons and astrocytes. Mechanistically, HITMAN activated unfolded protein response and autophagy pathways, suppressed cell cycle and adhesion genes, reduced Ki-67 expression, disrupted cytoskeletal architecture, and elevated p53 levels, underscoring a multifaceted antitumor mechanism. In orthotopic mouse models, HITMAN significantly inhibited tumor growth, extended median survival by over 50%, and showed no systemic toxicity. Thus, HITMAN offers a minimally invasive, potent, and clinically translatable therapy for GBM.","dates":{"publication":"2026/08/31"},"accession":"GSE324656","cross_references":{"GSM":["GSM9581729","GSM9581744","GSM9581733","GSM9581722","GSM9581743","GSM9581732","GSM9581721","GSM9581735","GSM9581724","GSM9581734","GSM9581723","GSM9581737","GSM9581726","GSM9581736","GSM9581725","GSM9581728","GSM9581739","GSM9581738","GSM9581727","GSM9581740","GSM9581731","GSM9581742","GSM9581741","GSM9581730"],"GPL":["18573"],"GSE":["324656"],"taxon":["Homo sapiens"]}}