{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324679/suppl/GSE324679_BTBR_counts.txt.gz","ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324679/suppl/GSE324679_cell_counts.txt.gz"],"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324679/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"," Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324679"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Characterize the effects of L. asaccharolyticus on autistic-like symptoms","description":"Accumulating evidence has revealed a strong link between the gut microbial community and ASD symptoms mediated by the gut–brain axis; however, ASD-specific microbial markers and the underlying mechanisms for targeted interventions remain unclear. Based on our previous identification of Lawsonibacter asaccharolyticus loss as a candidate ASD marker, we performed bacterial intervention in the BTBR ASD mouse model (C57 mice as healthy controls). Bulk RNA-seq was conducted on brain cortex and colon sections. In vitro validation: SH-SY5Y neuronal cells were treated for 24 h with bacterial filtrate, its derivative metabolite oleoylethanolamide (OEA), or butyrate (BA); untreated cells served as controls. All samples were subsequently analyzed by bulk RNA-seq.","dates":{"publication":"2026/04/10"},"accession":"GSE324679","cross_references":{"GSM":["GSM9582907","GSM9582906","GSM9582866","GSM9582865","GSM9582901","GSM9582868","GSM9582867","GSM9582900","GSM9582903","GSM9582902","GSM9582869","GSM9582905","GSM9582904","GSM9582871","GSM9582870","GSM9582873","GSM9582872","GSM9582875","GSM9582874","GSM9582899","GSM9582898","GSM9582857","GSM9582859","GSM9582858","GSM9582860","GSM9582862","GSM9582861","GSM9582864","GSM9582863","GSM9582888","GSM9582887","GSM9582889","GSM9582891","GSM9582890","GSM9582893","GSM9582892","GSM9582895","GSM9582894","GSM9582897","GSM9582896","GSM9582877","GSM9582876","GSM9582879","GSM9582878","GSM9582880","GSM9582882","GSM9582881","GSM9582884","GSM9582883","GSM9582886","GSM9582885"],"GPL":["34284","34290"],"GSE":["324679"],"taxon":["Mus musculus"," Homo sapiens"]}}