GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324679/suppl/GSE324679_BTBR_counts.txt.gzftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324679/suppl/GSE324679_cell_counts.txt.gzftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324679/primaryOK200TranscriptomicsMus musculus Homo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324679GEOGSEfalseCharacterize the effects of L. asaccharolyticus on autistic-like symptomsAccumulating evidence has revealed a strong link between the gut microbial community and ASD symptoms mediated by the gut–brain axis; however, ASD-specific microbial markers and the underlying mechanisms for targeted interventions remain unclear. Based on our previous identification of Lawsonibacter asaccharolyticus loss as a candidate ASD marker, we performed bacterial intervention in the BTBR ASD mouse model (C57 mice as healthy controls). Bulk RNA-seq was conducted on brain cortex and colon sections. In vitro validation: SH-SY5Y neuronal cells were treated for 24 h with bacterial filtrate, its derivative metabolite oleoylethanolamide (OEA), or butyrate (BA); untreated cells served as controls. All samples were subsequently analyzed by bulk RNA-seq.2026/04/10GSE324679GSM9582907GSM9582906GSM9582866GSM9582865GSM9582901GSM9582868GSM9582867GSM9582900GSM9582903GSM9582902GSM9582869GSM9582905GSM9582904GSM9582871GSM9582870GSM9582873GSM9582872GSM9582875GSM9582874GSM9582899GSM9582898GSM9582857GSM9582859GSM9582858GSM9582860GSM9582862GSM9582861GSM9582864GSM9582863GSM9582888GSM9582887GSM9582889GSM9582891GSM9582890GSM9582893GSM9582892GSM9582895GSM9582894GSM9582897GSM9582896GSM9582877GSM9582876GSM9582879GSM9582878GSM9582880GSM9582882GSM9582881GSM9582884GSM9582883GSM9582886GSM95828853428434290324679Mus musculus Homo sapiens