{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324743/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324743"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Hepatocytes promote liver metastasis of pancreatic cancer by providing exogenous serine","description":"The liver is the major site of metastasis for pancreatic ductal adenocarcinoma (PDAC). In this work, we describe a mechanism wherein serine sythensis is essential for PDAC liver metastasis. To describe this, we knocked out Phgdh in mouse KPC cells and then co-cultured the cells with mouse hepatocytes. Published DOI: 10.1038/s41586-026-11051-z Date: 23 Sept 2026","dates":{"publication":"2026/07/01"},"accession":"GSE324743","cross_references":{"GSM":["GSM9584704","GSM9584705","GSM9584713","GSM9584702","GSM9584703","GSM9584708","GSM9584709","GSM9584706","GSM9584707","GSM9584696","GSM9584697","GSM9584694","GSM9584695","GSM9584711","GSM9584700","GSM9584701","GSM9584712","GSM9584698","GSM9584710","GSM9584699","GSM9584692","GSM9584693","GSM9584690","GSM9584691"],"GPL":["24247"],"GSE":["324743"],"taxon":["Mus musculus"],"PMID":["[42778596]"],"DOI":["10.1038/s41586-026-11051-z"]}}