GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324743/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324743GEOGSEfalseHepatocytes promote liver metastasis of pancreatic cancer by providing exogenous serineThe liver is the major site of metastasis for pancreatic ductal adenocarcinoma (PDAC). In this work, we describe a mechanism wherein serine sythensis is essential for PDAC liver metastasis. To describe this, we knocked out Phgdh in mouse KPC cells and then co-cultured the cells with mouse hepatocytes. Published DOI: 10.1038/s41586-026-11051-z Date: 23 Sept 20262026/07/01GSE324743GSM9584704GSM9584705GSM9584713GSM9584702GSM9584703GSM9584708GSM9584709GSM9584706GSM9584707GSM9584696GSM9584697GSM9584694GSM9584695GSM9584711GSM9584700GSM9584701GSM9584712GSM9584698GSM9584710GSM9584699GSM9584692GSM9584693GSM9584690GSM958469124247324743Mus musculus[42778596]10.1038/s41586-026-11051-z