{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324814/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Mus musculus"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324814"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Spatial transcriptomics dissects mechanism of action of the PD-1 targeted IL15-mutein in B16-F10-OVA tumor-bearing mice","description":"KD050 is an anti-PD-1/IL-15 bi-functional antibody with strong PD-1 antagonist function, but lower lymphocyte stimulation enabled by a novel mutation on the IL-15. Here, we spatially characterized at RNA level the effect of mKD050 surrogate I in B16-OVA (melanoma) mouse model, in comparison with anti-mPD1 and mouse non-targetKD050 (mntKD050).","dates":{"publication":"2026/04/20"},"accession":"GSE324814","cross_references":{"GSM":["GSM9586608","GSM9586607","GSM9586606","GSM9586605","GSM9586609","GSM9586611","GSM9586610","GSM9586615","GSM9586614","GSM9586613","GSM9586612","GSM9586600","GSM9586604","GSM9586603","GSM9586602","GSM9586601","GSM9586509","GSM9586508","GSM9586629","GSM9586507","GSM9586628","GSM9586506","GSM9586627","GSM9586633","GSM9586512","GSM9586511","GSM9586632","GSM9586510","GSM9586631","GSM9586630","GSM9586516","GSM9586637","GSM9586636","GSM9586515","GSM9586514","GSM9586635","GSM9586513","GSM9586634","GSM9586619","GSM9586618","GSM9586617","GSM9586616","GSM9586622","GSM9586501","GSM9586500","GSM9586621","GSM9586620","GSM9586505","GSM9586626","GSM9586625","GSM9586504","GSM9586503","GSM9586624","GSM9586502","GSM9586623","GSM9586409","GSM9586408","GSM9586529","GSM9586407","GSM9586528","GSM9586413","GSM9586534","GSM9586533","GSM9586412","GSM9586411","GSM9586532","GSM9586410","GSM9586531","GSM9586417","GSM9586538","GSM9586416","GSM9586537","GSM9586536","GSM9586415","GSM9586414","GSM9586535","GSM9586530","GSM9586519","GSM9586639","GSM9586518","GSM9586517","GSM9586638","GSM9586402","GSM9586523","GSM9586644","GSM9586522","GSM9586643","GSM9586401","GSM9586642","GSM9586400","GSM9586521","GSM9586520","GSM9586641","GSM9586527","GSM9586406","GSM9586405","GSM9586526","GSM9586404","GSM9586525","GSM9586645","GSM9586403","GSM9586524","GSM9586640","GSM9586309","GSM9586308","GSM9586429","GSM9586556","GSM9586314","GSM9586435","GSM9586313","GSM9586434","GSM9586555","GSM9586433","GSM9586554","GSM9586312","GSM9586553","GSM9586311","GSM9586432","GSM9586318","GSM9586439","GSM9586559","GSM9586317","GSM9586438","GSM9586316","GSM9586437","GSM9586558","GSM9586436","GSM9586557","GSM9586315","GSM9586310","GSM9586431","GSM9586552","GSM9586430","GSM9586551","GSM9586550","GSM9586419","GSM9586539","GSM9586418","GSM9586424","GSM9586545","GSM9586303","GSM9586302","GSM9586423","GSM9586544","GSM9586301","GSM9586422","GSM9586543","GSM9586542","GSM9586300","GSM9586421","GSM9586307","GSM9586428","GSM9586549","GSM9586427","GSM9586548","GSM9586306","GSM9586547","GSM9586305","GSM9586426","GSM9586304","GSM9586425","GSM9586546","GSM9586420","GSM9586541","GSM9586540","GSM9586209","GSM9586215","GSM9586336","GSM9586457","GSM9586578","GSM9586456","GSM9586577","GSM9586214","GSM9586335","GSM9586576","GSM9586213","GSM9586334","GSM9586455","GSM9586333","GSM9586454","GSM9586575","GSM9586212","GSM9586219","GSM9586218","GSM9586339","GSM9586459","GSM9586217","GSM9586338","GSM9586579","GSM9586216","GSM9586337","GSM9586458","GSM9586570","GSM9586453","GSM9586574","GSM9586211","GSM9586332","GSM9586573","GSM9586210","GSM9586331","GSM9586452","GSM9586330","GSM9586451","GSM9586572","GSM9586450","GSM9586571","GSM9586319","GSM9586204","GSM9586325","GSM9586446","GSM9586567","GSM9586324","GSM9586445","GSM9586566","GSM9586203","GSM9586444","GSM9586565","GSM9586202","GSM9586323","GSM9586201","GSM9586322","GSM9586443","GSM9586564","GSM9586208","GSM9586329","GSM9586207","GSM9586328","GSM9586449","GSM9586327","GSM9586448","GSM9586569","GSM9586206","GSM9586447","GSM9586568","GSM9586205","GSM9586326","GSM9586321","GSM9586442","GSM9586563","GSM9586200","GSM9586562","GSM9586320","GSM9586441","GSM9586440","GSM9586561","GSM9586560","GSM9586479","GSM9586237","GSM9586358","GSM9586599","GSM9586236","GSM9586357","GSM9586478","GSM9586235","GSM9586356","GSM9586477","GSM9586598","GSM9586476","GSM9586597","GSM9586234","GSM9586355","GSM9586239","GSM9586238","GSM9586359","GSM9586350","GSM9586471","GSM9586592","GSM9586470","GSM9586591","GSM9586590","GSM9586596","GSM9586233","GSM9586354","GSM9586475","GSM9586353","GSM9586474","GSM9586595","GSM9586232","GSM9586473","GSM9586594","GSM9586231","GSM9586352","GSM9586593","GSM9586230","GSM9586351","GSM9586472","GSM9586347","GSM9586468","GSM9586589","GSM9586226","GSM9586467","GSM9586588","GSM9586225","GSM9586346","GSM9586224","GSM9586345","GSM9586466","GSM9586587","GSM9586344","GSM9586465","GSM9586586","GSM9586223","GSM9586229","GSM9586228","GSM9586349","GSM9586227","GSM9586348","GSM9586469","GSM9586460","GSM9586581","GSM9586580","GSM9586464","GSM9586585","GSM9586222","GSM9586343","GSM9586221","GSM9586342","GSM9586463","GSM9586584","GSM9586341","GSM9586462","GSM9586583","GSM9586220","GSM9586582","GSM9586340","GSM9586461","GSM9586259","GSM9586258","GSM9586379","GSM9586499","GSM9586257","GSM9586378","GSM9586256","GSM9586377","GSM9586498","GSM9586493","GSM9586251","GSM9586372","GSM9586250","GSM9586371","GSM9586492","GSM9586370","GSM9586491","GSM9586490","GSM9586376","GSM9586497","GSM9586255","GSM9586496","GSM9586254","GSM9586375","GSM9586253","GSM9586374","GSM9586495","GSM9586373","GSM9586494","GSM9586252","GSM9586248","GSM9586369","GSM9586247","GSM9586368","GSM9586489","GSM9586367","GSM9586488","GSM9586246","GSM9586487","GSM9586245","GSM9586366","GSM9586249","GSM9586361","GSM9586482","GSM9586240","GSM9586360","GSM9586481","GSM9586480","GSM9586244","GSM9586365","GSM9586486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