GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324892/primaryOK200Genomics Mus musculusHomo sapiensGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324892GEOGSEfalseSystematic Benchmarking of CUT&Tag Improves the Reliability and Reproducibility of Chromatin Analysis IICleavage under target and tagementation (CUT&Tag) is a widely used assay for analyzing epigenomic localization of proteins and histone PTMs. This study is focused on increasing the reproducibility of CUT&Tag through standardization of both wet bench and downstream data analysis. We find that 10K cells is the minimum input requirement for robust genome-wide profiling of H3K27ac, H3K9me3, H3K4me3, and H3K36me3 in mESCs cells.2026/07/16GSE324892GSM9588456GSM9588457GSM9588458GSM9588459GSM9588474GSM9588452GSM9588453GSM9588475GSM9588476GSM9588454GSM9588455GSM9588470GSM9588471GSM9588472GSM9588450GSM9588451GSM9588473GSM9588449GSM9588445GSM9588467GSM9588468GSM9588446GSM9588469GSM9588447GSM9588448GSM9588463GSM9588442GSM9588464GSM9588465GSM9588443GSM9588466GSM9588444GSM9588460GSM9588461GSM95884623428434290324892 Mus musculusHomo sapiens[42285100]