{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324997/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324997"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Hepatocytes promote liver metastasis of pancreatic cancer by providing exogenous serine, 2.","description":"The liver is the major site of metastasis for pancreatic ductal adenocarcinoma (PDAC). In this work, we describe a mechanism wherein serine sythensis is essential for PDAC liver metastasis. To describe this, we knocked out Phgdh in mouse KPC cells and then co-cultured the cells with mouse hepatocytes.","dates":{"publication":"2026/07/28"},"accession":"GSE324997","cross_references":{"GSM":["GSM9590343","GSM9590344","GSM9590352","GSM9590341","GSM9590342","GSM9590350","GSM9590340","GSM9590349","GSM9590338","GSM9590339","GSM9590336","GSM9590347","GSM9590348","GSM9590337","GSM9590345","GSM9590346"],"GPL":["24247"],"GSE":["324997"],"taxon":["Mus musculus"],"PMID":["[42778596]"]}}