GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325173/primaryOK200TranscriptomicsRattus norvegicusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325173GEOGSEfalseAntiretroviral therapy in the peripartum period impairs post pregnancy cardiac reverse remodeling in a rodent modelCardiovascular disease is the leading cause of maternal death worldwide and is linked to the cardiometabolic changes that support fetal growth. Normally, these changes reverse after pregnancy, but impaired reverse remodeling (RR) increases future cardiovascular risk. Pregnant individuals with HIV may face added risk, potentially from chronic viremia or antiretroviral therapy (ART). Many ART regimens include nucleoside reverse transcriptase inhibitors (NRTIs), which can cause mitochondrial toxicity and affect heart function. Using a rat model, we found that NRTI-containing ART disrupts pregnancy-related cardiac RR by inducing mitochondrial changes in the heart and liver, causing dyslipidemia and reduced cardiac function. Data herein include heart and liver gene expression that was evaluated by RNA sequencing in adult female rats treated with combinational antiretroviral therapy (cART).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 norvegicus